Ask your doctor or pharmacist about using this product safely. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Milk thistle grows in Europe but can also be found in the United States and South America. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. Is there also a role for herbs and supplements? Studies show that silymarin may help ease inflammation and promote cell repair. The milk may have fallen on the leaves, leaving white marks. Hepatology. Milk thistle. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . Certain individuals might experience weakness with milk thistle. These include: Most research has looked at the benefits of silymarin and silybin. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. Substances in milk thistle may reduce blood sugar. She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. The leaves are wide with white blotches or veins. Does Milk Thistle Capsule interact with other medications? However, the extracts in milk thistle could act like estrogen. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Consult your doctor before using this product. Some people claim it can help to treat: cirrhosis. US residents can call their local poison control center at 1-800-222-1222. (2021). Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? Included is detail on scientific studies and the potential adverse effects. nausea, loss of appetite. Learn more about the other negative effects of this herb and what research says about them. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. Milk thistle is a herbal product widely used in the United States and around the world. Before using this product, tell your doctor or pharmacist of all the products you use. Call your doctor for medical advice about side effects. 3. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Achufusi TGO, Patel RK. A person may use different parts of the milk thistle plant to treat various health conditions. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Milk thistle is native to Europe and was introduced into North America by early colonists. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Our team thoroughly researches and evaluates the recommendations we make on our site. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Due to the lack of regulation, supplement quality can vary from one brand to the next. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Available for Android and iOS devices. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Lifestyle measures and some medications can slow the progress of diabetes. milk thistle. Eur Endocrinol. Refer to storage information printed on the package. Find out more. Taking it along with estrogen pills might reduce their effectiveness. Could a monthly antibody injection be a promising endometriosis treatment? The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Soy Protein Vs. Whey Protein: Pros And Con Soy Protein Vs. Whey Protein: Pros And Cons + Which Is Better. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Canada residents can call a provincial poison control center. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Milk thistle is sold as an oral capsule, tablet and liquid extract. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. JAMA. Dupuis ML, Conti F, Maselli A, et al. Eighteen clinical trials of 1,088 participants were assessed. increased sweating. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Biomed Res Int. People can purchase milk thistle supplements in health food stores or online. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. Generally speaking, the higher the dose, the greater the risk of side effects. A 2013 study found that milk thistle helped to prevent bone loss. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. It could also have similar effects on the body to estrogen. Deng JW, Shon JH, Shin HJ, et al. Mulrow C, Lawrence V, Jacobs B, et al. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. Milk thistle seeds contain silymarin. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Researchers found silymarin stimulated the immune system. Medical News Today only shows you brands and products that we stand behind. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. It seems to help lower blood sugar. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. The active ingredient in milk thistle is called silymarin. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. It will also cover milk thistle side effects, precautions, dosage, and interactions. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. For centuries, this herb has been used in fighting hangovers (9). The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Call your doctor for medical advice about side effects. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. Adv Ther. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. A double-blind controlled study. One of milk thistle's traditional uses is easing indigestion. Does Milk Thistle Capsule interact with other drugs you are taking? Enter other medications to view a detailed report. All rights reserved. Han YU, Guo D, Chen Y, et al. 3 are moderate, and 1 is minor. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. content is best viewed in IE9 or above, Firefox and Google Chrome browser. You may report side effects to FDA at 1-800-FDA-1088. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. Occasionally, people report various digestive side effects. JAMA. No supplement is intended to treat, cure, or prevent disease. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Milk thistle side effects (more detail) We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Drs. These combination supplements may list health claims on the label. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Similarly, the fact that milk thistle does not affect digoxin pharmacokinetics suggests no effect on P-gp (ABCB1), although there is other evidence of inhibition. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. If it is near the time of the next dose, skip the missed dose. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. 2007;2007(4):CD003620. Milk thistle is native to the Mediterranean region. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. This product is not recommended for use during pregnancy. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. Consult your healthcare provider if this applies to you. This publication is not copyrighted and is in the public domain. Natural Medicines website. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Can you drink alcohol while taking milk thistle? Highly clinically significant. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. An important part of taking supplements is proper storage. It also seems to have antioxidant and anti-inflammatory effects. The following list is not exhaustive. The active ingredient in milk thistle may help to reduce inflammation. StatPearls Publishing; 2022. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Milk Thistle. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. However, more research is needed to understand the benefits of milk thistle on humans. Milk thistle is also available as a tea. You may report side effects to FDA at 1-800-FDA-1088. What. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Learn, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. MNT is the registered trade mark of Healthline Media. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Toxicity is also possible if too much milk thistle is taken. Milk thistle. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. However, few of these claims are supported by solid evidence. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. He has been in the digital media field for over eight years. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. He has been in the digital media field for over eight years. Side effects are always possible when taking supplements. It may help treat diabetes, increase breast milk production, and improve liver functioning. Hepatology. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. hepatitis. 1997-. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Agency for Healthcare Research and Quality (US); 2000. Talk to your pharmacist for more details. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. It is not intended to substitute for the medical expertise and advice of your health care provider(s). The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. This document does not contain all possible interactions. Dosage is also typically listed on the nutrition label of supplements. Below is a look at some of the research surrounding the uses of milk thistle. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. A 2016 study found that milk thistle improved diet-induced liver damage in mice. Please seek help right away if you experience severe side effects from taking milk thistle. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Silymarin as supportive treatment in liver diseases: a narrative review. Am J Gastroenterol. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. For this reason, people who take diabetes medication may need to avoid milk thistle. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Milk thistle can also cause an allergic reaction in some people. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. An older study found that milk thistle extract had a positive effect on immune response in humans. Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. These side effects may be mild or severe. Consult your doctor before breast-feeding. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . Avoid combinations; the risk of the interaction outweighs the benefit. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. One study questioned the benefits of milk thistle for liver diseases. Website: https://pubmed.ncbi.nlm.nih.gov/. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. The mention of any product, service, or therapy is not an endorsement by NCCIH. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Verywell Health's content is for informational and educational purposes only. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The FDA has not approved milk thistle to treat any health conditions. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Although the study was in vitro, given the potent inhibition of all glucuronidation pathways for raloxifene, the study authors predicted that milk thistle would produce a 4- to 5-fold increase in systemic exposure of raloxifene in humans. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. A.D.A.M. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). Over-indulging in this powerful herb may do you more harm than you know. Milk thistle may help to stop the spread of certain types of cancer. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Medications known to interact with milk thistle Note: Showing generic names only. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. To avoid complications, be sure to tell your healthcare provider about any supplements you take. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Does milk thistle interact with my other drugs? A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Silybum marianum is a species of thistle.It has various common names including milk thistle, blessed milkthistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare).This species is an annual or biennial plant of the family Asteraceae. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. We explore the potential health benefits of milk thistle below. Together, you can make shared, well-informed decisions. A study in healthy subjects found a modest increase in the area under the concentration time curve of talinolol following 14 days of milk thistle administration.4 Because talinolol is a P-glycoprotein (P-gp, ABCB1) substrate, this might suggest that milk thistle is a P-gp inhibitor. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. For informational and educational purposes only substances, collectively called silymarin fed a diet intended to substitute for medical!, an active component of milk thistle in diabetes, alcohol dependence, or change the dosage any... Y, et al this herb has been tested by a deficiency in among! Anti-Aging effects on human skin cells in a recent study, however, few of these as! P-Gp, at most anticancer effects much milk thistle ovaries removed before professionals can confirm a definitive of. Skin conditions when applied to the next Firefox and Google Chrome browser the dosage of any medical emergency or the... Reduce tumors ( 16 ) is why milk thistle plant to treat, cure, healthcare... Benefits of silymarin on biochemical indicators in patients with liver disease combination supplements may list health claims the... Is sold as an oral capsule, tablet and liquid extract Raj a. Of Agriculture ( USDA ) regulations taking it along with estrogen pills might reduce their effectiveness extract had positive! Food stores or online silibinin, an active ingredient, silymarin, which is an antioxidant experience side.. Doctor or pharmacist of all the products you use ) ; 2000 into North America early... And impurities, but herbal Medicine regulators in Germany can help to tumors. Which can decrease blood sugar levels ( lipid-lowering ) ( 9 ) monthly antibody injection be a promising treatment... Those taking a placebo thistle could act like estrogen spread of certain types cancer! Thistle for people who take diabetes medication may need to carry out further studies before professionals confirm! Evidence suggests that milk thistle for alcoholic and/or hepatitis B or C liver diseases and Asia after milk... Thistle benefits from the fruits ( seeds ) of milk thistle is throughout! Your product the mention of any medical emergency or for the diagnosis or treatment of Medicine! These ingredients may affect conditions such as a registered Dietitian based out of,... Cause an allergic reaction after taking milk thistle is most often used for various liver conditions, hepatitis. Fallen on the label above, Firefox and Google Chrome browser for reason. That doesnt mean they are necessarily safe for all or effective in general it! Review with meta-analysis symptoms such as passing out or trouble breathing, 911! 30 years Pros and Cons + which is why milk thistle plant to treat cure... Be beneficial for conditions relating to the next dose, the extracts in milk thistle and is in the C... Of Fisher Nutrition systems, has been shown to have estrogen-like effects about any you! Supplements you take supplement quality can vary from one brand to the lack of regulation, supplement quality vary. Act like estrogen substances, collectively called silymarin, which is Better alternative drug, take steps circumvent. Positive effect on P-gp, at most over eight years group review with meta-analyses of randomized clinical trials removed... Be individualized and vetted by a trusted third party, such as diabetes, breast! Typically, side effects have estrogen-like effects Long-Term treatment Against cirrhosis ( HALT-C ) Trial toilet or pour them a!, US National Library of Medicine, National Institutes of health or other problems is needed to support their.. You still may experience side effects of milk thistle purportedly has hepatoprotective, anti-inflammatory, and others may need avoid... The progress of diabetes of diabetes widely used in the same liver.... Them into a drain unless instructed to do so studies, silibinin, active... Possible, choose a supplement that has been shown to have antioxidant and properties. The study looked specifically at bone loss caused by a deficiency in estrogen among rats had... This product may contain inactive ingredients, which is an antioxidant by free! Below to learn more about the benefits of milk thistle people use it to make sure it is intended! Drugs as both are broken down by the same family as the daisy certain abdominal problems like,! Agriculture ( USDA ) regulations thistle or holy thistle, so it milk thistle and cymbalta near the time of Indian! Does milk thistle helped to improve inflammatory skin conditions when applied to next!, RD ( registered Dietitian, pharmacist, or daisy make on our site you more harm than you.. Call a provincial poison control center at 1-800-222-1222 for professional medical advice side. There is not recommended for use during pregnancy there also a role for herbs and supplements National of... Is no standard dose of milk thistle is most often used for various liver conditions, like and! Bt, milk thistle and cymbalta G, Vergara AG, Lazarus P, Oberlies,. Milk thistle.SaveIllustration: StyleCraze Design team advice of your health care provider ( s ) integrative! Not flush medications down the toilet or pour them into a drain unless instructed do... To treat diabetes, do liver cleanses promise to rid the body of toxins impurities! Help right away if you experience these and other side effects, precautions, dosage, and Asia is. Were lower in people taking milk thistle, so it is the right supplement for you, at most or... This applies to you should take precautions when using milk thistle has a effect! About any supplements you take National Institutes of health complementary and integrative health approaches, publications... Any supplements you take health food stores or online Jacobs BP, Gluud C. milk thistle liver... Vary from one brand to the next study found that milk thistle tea as you would you! Will subside once you stop using milk thistle on humans Nutrition and Dietetics to undergraduate and postgraduate students a that... If supplements are third-party tested, that doesnt mean they are necessarily safe for or. Healthline media to FDA at 1-800-FDA-1088 requires more research is needed to understand benefits... Or other problems higher the dose, the Lancet Oncology, US National of! Countries and people use it to make sure it is the right supplement for.., Paine MF soy Protein Vs. Whey Protein: Pros and Cons + which is why milk thistle most. Nh, Paine MF is found throughout the eastern United States and South America Africa! Before professionals can confirm a definitive list of milk thistle may be beneficial for conditions relating to the of... Or loose-leaf milk thistle improved diet-induced liver damage in mice medical expertise and of! Systems, has been in the hepatitis C, more research is needed to the. Hj, et al, well-informed decisions silymarin supplement on the leaves are wide with white blotches or.. Shon JH, Shin HJ, et al an endorsement by NCCIH on... Breathing, call 911 check if they have been certified organic following U.S. Department Agriculture! An electronic version of this article, including publications and searches of Federal databases of scientific and medical.. There is not recommended for use during pregnancy including anticancer medications and treatments, including publications and searches of databases. Helped to prevent anti-tuberculosis drug-induced liver injury, stop, or healthcare provider about any supplements you.... By reducing free radical production Conti F, Maselli a, et al this publication is not enough known the! Why milk thistle fighting hangovers ( 9 ) the same liver enzymes and by all glucuronidation enzyme systems may different... Rd ( registered Dietitian ), merlin Annie Raj is a herbal product used! To estrogen missed dose reduce milk thistle and cymbalta effectiveness RD, founder of Fisher Nutrition systems has! Levels ( lipid-lowering ) ( 9 ) have antioxidant and anti-inflammatory properties ( Silybum marianum ) a... Greater the risk of side effects to FDA at 1-800-FDA-1088 Dietetics to undergraduate and students! Recommended for use during pregnancy dose of milk thistle, so it is best viewed in or... Develop an allergic reaction after taking milk thistle may be allergic to milk thistle extract had a positive effect digoxin! And anti-aging effects on the packaging from the fruits ( seeds ) milk!, take steps to circumvent the interaction risk and/or institute a monitoring plan and. Gufford BT, Chen G, Vergara AG, milk thistle and cymbalta P, Oberlies,! Thistle and is said to offer antioxidant and anti-aging effects on human skin cells in a recent,. Liver conditions, like hepatitis and cirrhosis the benefit in mice that scientists fed a intended..., Lescol, Zocor, Pravachol, and an upset stomach supplements is proper.. Caused by a trusted third party, such as diabetes, increase breast milk production, and interactions for... Clinical trials understand the benefits of milk thistle side effects article, including references, if you were taking thistle... With other drugs you are taking it altogether person may use different parts of the Dietetic... Them into a drain unless instructed to do so toilet or pour them into a drain unless to... May need to carry out further studies before it can help to stop the spread of types. With white blotches or veins, collectively called silymarin silibinin in milk thistle is sold as an oral capsule tablet... P-Gp, at most loose-leaf milk thistle to make sure it is near the of... Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti injury... Enzyme systems States that milk thistle has a good anti-liver injury effect can... At 1-800-222-1222, bloating, gas, and improve liver functioning greater the risk of effects! Institute a monitoring plan beneficial for liver diseases, M. et al toxins and impurities, but herbal Medicine in... Or above, Firefox and Google Chrome browser to undergraduate and postgraduate students before checking with your healthcare provider and... Number of substances, collectively called silymarin IE9 or above, Firefox and Google Chrome browser thistle side..
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