An enzyme-linked immunosorbent assay should be considered to detect anticyclic citrullinated peptide antibodies in patients with a moderate clinical pretest probability of rheumatoid arthritis. Being able to perform additional testing and maximize an instruments utilization could make an MIA system an attractive option. Like having Lyme isn't enough, you have to deal with this. Importantly, for ANA positive samples, the identities of the antigen specificities are not revealed to the laboratory and thus are not reported to patients medical records. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. A positive ANA test means that a person may have an autoimmune disease, depending on the titre. Once a patient has a positive ANA titer, it is rarely helpful to repeat the test; ANA levels fluctuate and do not reflect disease activity. It unravels bit by bit and MOST people with a +ANA are absolutely healthy. See our Privacy Policy for more details. Keywords: Antinuclear antibodies; DFS70; Dense fine speckled; Lens epithelium-derived growth factor; Systemic autoimmune rheumatic disease. Save time on interpreting lab results with the largest database of biomarkers online. well, I have been on AP and Lyme treatment for 23 months now. Conversely, if one or more of the beads show fluorescence exceeding a certain threshold, a sample would be identified as positive. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. The pattern of ANA is helpful in determining what, if any, auto-immune disease you might have. I'd agree with your doctor on this one. If a patient's anti-ANA test is positive and they have clinical features of an autoimmune disease, other more specific tests will usually be ordered to help reach a diagnosis. The antigen specificity associated with this pattern has been identified as lens epithelial-derived growth factor, also referred to as DFS70 (8). Another advantage of MIA systems is they offer labs the opportunity to expand their test menus. You can a positive ANA from a variety of conditions besides autoimmune disease. Drug induced . Has he got you on a treatment plan for your symptoms?? In a group of 100 randomly selected people, about 30 would have an ANA positive test at the 1:40 titre, about 10 would be positive at the 1:80 titre, and 3 would be positive at a 1:160 titre. I'm sorry this is so frustrating. For samples identified as positive, the computer algorithm reads the pattern of and interprets the fluorescence intensities in the context of known ANA patterns. A peripheral pattern indicates that fluorescence occurs at the edges of the nucleus in a shaggy appearance; this pattern is almost exclusive to systemic lupus. Nuclear, speckled, etc. This does not mean you do not have an autoimmune disease but it is likely that you don't have systemic disease (organ and blood involvement). I appreciate your insight. There ARE those with lupus who have negative ANA . The enzyme linked to the detection antibody converts a colorless substrate to a colored product, the absorbance of which is compared to a standard curve. Patients can present with symptoms such as recurrent sinusitis, epistaxis, airway inflammation, neuropathy, and glomerulonephritis. But if you check out the links I've given you in my signature and then do some searching on interesting aspects (like nutrition), you will have educated yourself. Although this condition is rare, antibody testing can help with the diagnosis. . All of the additional tests were negative and she has no other symptoms. 2 doctor answers 4 doctors weighed in My ANA is positive and speckled Write by: Mine has been all over the place as well, but it was not noticed until it was 1:2,560. A speckled pattern is also found in lupus. I might also could be playing a role in your seizures but your doctor would know for sure. Many laboratories that perform ANA by IIF are moving away from screen-ing at the 1:40 dilution, opting for improved specificity even with some loss in sensitivity. Systemic lupus erythematosus (SLE) is the prototypic autoimmune disease characterized by production of autoantibodies resulting in end-organ inflammation. But DO hang on to your copy of each blood work that you get and keep a file. She reports moderate depression, but the review of systems is otherwise negative. February 27, 2023 endeavor air pilot contract No Comments . I don't have the time to read through all the responses, so if I repeat something that was said, I am sorry. A low ANA titer (1:40 to 1:80) may be associated with preclinical disease or lack of disease. Fevers and sleep apnea are also common in lupus. The sensitivity and specificity of a positive ANA result are 48% and 52%, respectively; the LR+ is 0.99, and the LR is 1.01.11, Sjgren antibodies may also be present when the syndrome develops in patients with other connective tissue disorders. IIFs sensitivity is attributed to its broad antigen specificity. I went in to see her and she asked me questions about any possible symptoms. The titer shows how many times the patient's serum was diluted before the antibodies could no longer be detected. Is it Wallace? We can't diagnose, but Vee and I both have lupus (I just now saw her post after writing all this), so sorry for the duplication.) Although IIFs have the capability of maximizing sensitivity, from a practical perspective, EIAs and MIAs provide a good balance of sensitivity and specificity. The ANA test is used as a screening test for autoimmune diseases including rheumatic diseases such as Systemic Lupus Erythematosus, and for non-rheumatic diseases such as autoimmune liver diseases, autoimmune thyroid diseases, and autoimmune bowel diseases. A positive anticyclic citrullinated peptide antibody titer is more specific for rheumatoid arthritis and can help confirm the diagnosis. Ironically I have several AI diseases. My question is--the pattern has always been speckled, and now for the first time it has changed to nucleolar. Testing for antineutrophil cytoplasmic antibodies is not indicated in the evaluation of patients with sinusitis who have no other features of vasculitis. When the immune system sees nuclear proteins, a normal response is to try to make antibodies to the proteins. Anti-Smith antibodies have the greatest specificity for SLE (98.6%) and are included in the diagnostic criteria for SLE.13 However, their sensitivity is low (39.7%). Thus, a titer of 1:640 shows a greater concentration of ANA than 1:40. Usually, the results of the ANA test are reported in titers and patterns. It really gets confusing with the ANA patterns due to the overlap of several Connective Tissue Disease. It would be so much easier to spell, LOL) Umm, again, as both ladies have said, getting your thyroid disease treated will help a lot in feeling better. Imagine your lab has decided to take the plunge and implement antinuclear antibody (ANA) testing in house, taking it off the send-out menu. Autoimm Rev 2014;14:292-8. In 2020, it was at 1:1280 titer (speckled pattern). She called me and told me that all was negative and that we would just continue to monitor it. Pattern on the antinuclear antibody-HEp-2 test is a critical parameter for discriminating antinuclear antibody-positive healthy individuals and pa-tients with autoimmune rheumatic diseases. Do not copy or redistribute in any form! A strongly positive ANA test means that it is more likely that a person has an autoimmune disease. Everything else came out negative, but a few were very boarder line such as Circulating Immune Complex 19.1 ( borderline range 20-25), RF IgM 3. The titer is determined by serial dilution, with the reported titer being the last dilution for which the IIF would be identified as positive. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. The antinuclear antibody test looks for antibodies that bind to a . Diffuse. (I think they should just give it a symbol as it's name, like the singer formerly known as Prince. It was kinda high. ANA are antibodies produced by the immune system that bind to the body's own tissues. . Therefore, no further immuno-logic tests are warranted. First described more than 50 years ago, ANAs remain the most sensitive serologic mark-er for evaluating patients with suspected connective tissue diseases (CTDs), also referred to as ANA-associated rheumatic diseases (AARDs) (1). However, positive test results do not tell what type of autoimmune disease it is. . 9 more days, yay! 0 - 0 %. The ANA could result from chronic infections. Antidouble-stranded DNA antibodies are a hallmark of SLE. It's on the Healing Well list of books. At this point she ran a bunch of things which included the ANA test. These are all chronic When we increased the cutoff for IIF to 1:80, the specificity improved to 62% but the sensitivity decreased to 84%. It may help later when a pattern starts to emerge. WebThe group has defined six nuclear patterns as Competent-Level: homogeneous; speckled; dense fine speckled (DFS); centromere; discrete nuclear dots; and nucleolar. ANA staining pattern was identified by treating cultured human epithelial type 2 (HEp-2) cells with the sera of the There are very few specific signs of lupus; two antibodies:anti ds- DNA which is found in maybe 50% of those who have a lupus diagnosis and is regarded as specific but can occasionally be found in a few other diseases, and anti -Sm ( Smith) which is regarded as100% specific but only 30% of those with lupus have them. International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. Common diseases are presented with typical symptoms, and an overview of appropriate testing is provided. shows in other bloodwork, so your doc should have picked up on that if she thought of it. . A speckled pattern may indicate various diseases, including She some symptoms but nothing that is enough to treat The erythrocyte sedimentation rate (ESR) is a crude measure of inflammation. Titers >1:80 are consistent with autoimmune disease. are ana titers dependable? //
We aimed to determine the significance of cytoplasmic antinuclear antibody (ANA) patterns using computer-aided immunofluorescence microscopy in patients with autoimmune liver diseases (AILD). but don't buy into any commercials and people selling stuff. WebA speckled pattern is also found in lupus. Related letter: Additional Rheumatologic Tests Critical in Patients with Systemic Sclerosis. Watch what happens when you are exposed to sunlight. A low ANA titer (1:40 to 1:80) may be associated with preclinical disease or lack of disease. ago. Scheduled for biopsy. This decision guide is designed for persons with a positive antinuclear antibody (ANA) who would like to find out more about this test and what the test result But, again, if you are symptom free . thoughts??? WebAn ANA-HEp-2 test result was considered positive when a clear ANA pattern was observed at 1:80 dilution in 2 distinct commercial HEp-2 slides by 2 blinded independent observers. ANA titers can be falsely positive in many diseases that are characterized by autoimmunity and nonspecific antibody production. Your symptoms could be related to connective tissue disease. There is no traceable standard for these assays, so each manufacturer establishes the units and analytical measuring range for its tests. However, when the immune system can "see" the nuclear contents for longer periods of time, it can mount a significant antibody response. Second, for patients with positive screening assay results, additional tests characterize the antigen specificity of their ANA. Anti-DFS70 antibodies: An update on our cur-rent understanding and their clinical usefulness. Date: APR.1.2019
Its hard to post everything here . that will give you the gold standard for diagnoses, even w/o a +ANA. Pisetsky DS. Nat Rev Rhem 2017;13:495-502. A negative test is strong evidence against a diagnosis of SLE but not conclusive. Nucleolar Pattern, 1:80, and Dense Fine Speckled Pattern, 1:320. Thanks replying it means a lot to talk with someone about these issues. Optimal Result: Hi & welcome. These include Hashimoto thyroiditis, autoimmune liver disease, viral infections such as hepatitis C and human immunodeficiency virus infections, some cancers, pulmonary fibrosis, and type 1 diabetes mellitus. You should ask this question to the doctor who ordered the test. WebWhat does ANA titer 1 80 speckled mean? A positive ANA test means there are antibodies in the blood against proteins in the cell nucleus. Another pattern, known as a nucleolar pattern, is common in people with scleroderma. Write by: Mine has been all over the place as well, but it was not noticed until it was 1:2,560. The ANA staining patterns are loosely associated with underlying autoimmune diseases. C-reactive protein (CRP) is more sensitive than ESR for detecting inflammation. Re: AI Diagnosis Question - 1:640 ANA+ Speckled Pattern. Description. In comparison, the corresponding EIA and MIA specificities were 80% and 87%, respectively. When the ANA test is positive, other tests are required to identify which protein(s) the antibodies are attacking such as the anti-dsDNA test and the ENA panel. Autoimmunity is when the body has failed to recognize a part of itself, and the immune system has mounted a response against the body's own cells and tissues. A positive RF titer in a patient with joint pain increases the probability of rheumatoid arthritis. The lowest dilution is 1:2560. The clinical hallmark is dryness of the mouth and eyes (xerostomia and sicca). Any sample identified as positive at the screening dilution is titered out either to endpoint or to a pre-defined dilution, depending on the laboratorys preference. Acetylcholine Receptor Ganglionic (Alpha 3) AB, TSI - Thyroid-Stimulating Immunoglobulin, Serum. ANA 1:40 is found in 20 30% of healthy people; ANA 1:80 is found in 10 15% of healthy people; ANA 1:160 is found in 5% of healthy people; ANA 1:320 is found in The body normally makes anti-nuclear antibodies for brief periods of time. Your test results indicate an autoimmune process of some sort AND youre symptomatic. More complex patterns unidentifiable by the computer still require a technologists interpretation. The patterns seen are as follows: Homogenous is the most common and the least concerning pattern of ANA. Certain laboratories use a reference number and use an arbitrary unit of measurement to indicate a result that is above the reference figure, as positive. Hi Directrpep, Actually . The positive predictive value (PPV) for significant AiD was considerably high on application of an ANA titer of 1:640, and the PPV of a dense fine speckled (DFS) pattern was significantly lower compared with those of speckled and homogenous patterns. Can chronic viruses like Epstein-Barr cause such a high ANA? Each bead set is conjugated to a known ANA antigen, and the different sets are then combined into a bead cocktail. HLA-B27 is also present in up to 6% of healthy persons in the United States32; therefore, testing should not be performed routinely in patients with back pain. Give it awhile, monitoring your ANA and you'll probably start to see a difference in the other lupus tests. Front Immunol 2015;6:1-13 When labs use higher screening dilutions, the sensitivities of IIFs are on par with those of EIAs and MIAs. Meanwhile it's too soon to be worried about it. LE cells could be produced in vitro by taking patient plasma and mixing it with peripheral blood from healthy controls that had been damaged by vortexing with glass beads. ANA pattern refers to the distribution of staining produced by autoantibodies reacting with antigens in these Being a male does not exclude the d A diagnosis is made on the basis of the entire clinical picture but a positive ANA and DNA could suggest lupus if the clinical picture fits. So, when I called the office to get the results, she told me that it was high and wanted to see me again to run more tests. Anti-nuclear antibodies are a type of autoantibody: they are an antibody produced by the immune system and they target something that the body's own tissues are made out of. In addition to ANA testing, a complete metabolic panel can be ordered to evaluate renal and hepatic function; a complete blood count with differential can help screen for lymphopenia, thrombocytopenia, and anemia; and urinalysis with microscopy can assess for hematuria, pyuria, and proteinuria. Getting a little anxious at this point. I tested positive for ANA, it is 1:160 with a speckled and homogenous pattern. Although seemingly very straight-forward, these types of comparisons are more difficult than they appear, largely because estimated sensitivities and specificities and the agreement between methods is heavily dependent on the cutoffs used to differentiate between positive and negative. What do you think? Physicians should order these serologic tests only when patients have a high pretest probability of a specific connective tissue disorder. ANA by IIF is generally reported with both a titer and a pattern. Your symptoms or what organ systems that are involved early in the disease course can sometim That ANA is positive. This diluted sample is tested for the presence of ANA antibodies. ANA 1:40 yawn. WebThe ANA was 1:640 & speckled. Actually, i went to the doctor for just a simple check up. The speckled pattern is one that's not specific to a particular disease but can occur in lupus, scleroderma, etc. Speckled is a pattern that often occurs in lupus. There's a great book but the name eludes me. Some data suggest that the titer of the ANA may help in distinguishing between patients with and without AARDs. Email: [emailprotected]. The ANA test gives two types of results: 1) the titre, and 2) the pattern. Its pooled sensitivity and specificity are 67% and 95%, respectively; the LR+ is 12.46, and the LR is 0.36.26, Positive anticyclic citrullinated peptide antibody titers may provide information about prognosis and the likelihood of developing erosive disease.27 However, serial monitoring of these titers is not recommended because variations do not correlate with response to therapy.26. EIAs quantitation is based on light absorbance. WebThe antinuclear antibody panel is a blood test that looks at antinuclear antibodies (ANA). . Does a positive ANA of 1;640 spec pattern suggest cancer if all other test are negative? For these, please consult a doctor (virtually or in person). Chan EKL, Damoiseaux J, Carballo OG, et al. Ive repeatedly read that the titres caused by viruses and bacterial infections are usually mild, presumably <640. Speckled: Fine and coarse speckles of ANA staining are seen throughout the nucleus. This pattern is more commonly associated with antibodies to extractable nuclear antigens. This pattern can be associated with Systemic Lupus Erythematosus, Sjgrens syndrome, Systemic Sclerosis, Polymyositis, and Rheumatoid Arthritis. The fluorescence intensity of the stain is measured, and values above a certain cutoff are considered positive. All Articles
ANAs refer to a collection of autoantibodies that target a variety of nuclear and cytoplasmic antigens. The diagnostic potential of ANAs originated with the discovery of LE cells, described as ma-ture polymorphonuclear leukocytes containing phagocytosed nuclear material. This article gives a framework for laboratory testing in patients with a suspected connective tissue disease. My guess is that you may have lupus, or a cousin to it, with the ANA that high. Case 2: M.A. is a 22-year-old African American female with SLE with positive ANA, positive anti-dsDNA, low complements, cytopenias with lupus nephritis on hemodialysis, cardiomyopathy and serositis. Thanks so much to both of you. speckled pattern. I've had to wait almost a year to get in, and finally am this month. The hallmark of a connective tissue disorder is synovitis, which may be accompanied by other features such as the Raynaud phenomenon, serositis, nephritis, or decreased platelet or leucocyte count. I might not remember it exactly, but it goes something like this. . TheLupusLab 7 mo. For example, when these antibodies are detected in patients with rheumatoid arthritis, the risk of secondary Sjgren syndrome is increased. In-depth research on any test at your fingertips, all stored and tracked in one place. Now, however, systems are available that automate almost the entire process, from slide processing to reading. WebRheumatoid arthritis (RA): when ANA positive (about 25-40% of cases), a speckled ANA pattern most commonly. WebThe PPV of the speckled pattern for AASRD was 13%, 39%, 32%, and 71% for a titre of 1:160, 1:320, 1:640 and 1:1280, respectively. From a physicians perspective, one of the most obvious differences between ANA screening methods is how results are reported. Sometimes it can take awhile. The pattern interpretation is based upon recognition of specific cellular features to which a patients antibody has bound (Figure 1). Elevated ESR is one of the American College of Rheumatology classification criteria for polymyalgia rheumatica.33 It has a sensitivity of 80% for polymyalgia rheumatica and 95% for temporal arteritis.34 The ESR generally increases with age because of changes in fibrinogen levels that affect the fall rate of red blood cells during testing. If you don't have any symptoms . If it's positive, they should go on and check the rest of it. This test is positive but only the doctor ordering it can explain to you the significance. Her ANA titer is 1:80, with a homogenous pattern. Did your doctor just run the ANA titer or did he try checking for autoantibodies too? I have symptoms of aches and pain in my knees and my hands. Recently, symptoms have increased, and my ANA is 1:640 dense fine speckled. A low ANA titer (1:40 to 1:80) may be associated with preclinical disease or lack of disease. Rheumatoid arthritis is a symmetric small-joint arthropathy affecting the hands, wrists, and feet and is associated with joint pain and morning stiffness. As a general rule, if a person's ANA test is negative, then they do not have lupus. Do not test ANA subserologies without a positive ANA test result and clinical suspicion of immune-mediated disease. WebAnti-RuvBL1/2 autoantibodies have recently been detected in patients with systemic sclerosis (SSc) and scleromyositis overlap syndromes. Blessings! Another pattern, known as a nucleolar pattern, is common in people with scleroderma. These are very complicated illnesses and they take awhile to diagnose, get treatment underway, and respond to treatment, but there is hope and you are on your way to feeling better! Interpret your laboratory results instantly with us. Some automated readers not only automate pattern interpretation at least partially but also estimate titers. AACC.org
If your doctor hasn't scheduled you for a follow-up, make sure to do so w/i a few months to make sure those numbers are holding or going down. Systemic Lupus Erythematosus (SLE) is an example of an autoimmune disease. your liver numbers is what I would be checking out. Materials and Methods: ANA patterns and positivity of antibodies against nuclear antigens (NA), in particular those responsible for a nucleolar ANA pattern and/or associated with systemic sclerosis (CENP-A/B, fibrillarin, Ku, NOR-90, PM/Scl-100, PM/Scl-75, RNAP-III, Scl-70, Ro52/TRIM21, and Th/To) were analyzed and correlated to an ana-positive, titer >1:640, speckled/ana titer 2-1:32, ana pattern 2-homogeneous c3 180.8, rnpab, igg 1.5, crp 1.9. 21-Hydroxylase Antibodies, Acetylcholine Receptor Ganglionic (Alpha 3) AB, Ana Pattern, B2 GLYCOPROTEIN I (IGA)AB, B2 GLYCOPROTEIN I (IGG)AB, B2 GLYCOPROTEIN I (IGM)AB, CARNITINE ESTERS, Carnitine, Free, Carnitine, Total, CHROMOGRANIN A, COPEPTIN, Cortisol, Free, Urine, CORTISOL,FREE,LC/MS,S, ESTERIFIED/FREE RATIO, ESTRADIOL (Quest), GLUCOSE-6-PHOSPHATE DEHYDROGENASE, Glutamic Acid Decarboxylase 65 AB, HISTAMINE RELEASE (CHRONIC URTICARIA), HISTAMINE, PLASMA, IGF 1, LC/MS, IMMUNOGLOBULIN M, Immunoglobulin Subclass 4, LH, LKM-1 Antibody (IgG), LUPUS ANTICOAGULANT, Neuron Specific Enolase (NSE), PARATHYROID HORMONE, INTACT, PARTIAL THROMBOPLASTIN TIME, ACTIVATED, PREGNENOLONE, LC/MS, PROGESTERONE, LC/MS, PROSTAGLANDIN D2 (PG D2), URINE, PROSTAGLANDINS (PG D2), SERUM/PLASMA, PROSTAGLANDINS: (PLASMA/SERUM), PROTHROMBIN ANTIBODY (IGG), Soluble Liver Antigen (SLA) Autoantibody, T3 REVERSE, LC/MS/MS, T3, FREE, TESTOSTERONE,BIOAVAILABLE, Total Glutathione, TRYPTASE, TSI - Thyroid-Stimulating Immunoglobulin, Serum, Z SCORE (FEMALE), Z SCORE (MALE). Identifying the antigen specificity has important diagnostic and prognostic implications for patients. the "titre"). You should address this question to the doctor who ordered the test. You can change these settings at any time, but that may impair functionality on our websites. ANA 1:160 Raise the eyebrows (repeat if other concerns) ANA 1:320 Sit up and take notice (definitely repeat) ANA 1:640 Reach out to the phone and call a rheumatologist for a future appointment. The hallmark of SLE is the presence of ANA, which is found in more than 95% of affected patients.3 The likelihood of SLE is low in patients with negative ANA titers who do not have the full constellation of symptoms (e.g., only joint pain and rash). Maybe they'll be able to help you feel better. The antioxidents in the fruit are great. In contrast, EIAs are batched, which, for labs with lower volumes of ANA orders, could have a negative impact on workflow and on turnaround times. 1:320), the result is less clear and should be interpreted in the clinical context, If the ANA titre is high, other tests may be ordered to determine what type of nuclear protein is being attacked. Many different types of proteins are found in the nucleus that perform many different functions. A fish finder indicates if there are any fish below the surface of the water, and gives an idea of how many are there. The nucleoli maybe stained or not stained depending on cell substrate. The International Consensus on ANA Patterns (ICAP), a subcommittee of the Autoantibody Standardization Committee, promotes discussion and generates consensus regarding the morphologic features associated with specific ANA patterns (4). Patients classically present with the Raynaud phenomenon, pulmonary hypertension, arthritis, and myositis. I'm set to get more testing done soon. It should not be used in patients with routine sinusitis unless some features of systemic vasculitis are present.29,30.
In SLE, the ANA result will commonly have a homogeneous or rim pattern. It took two years of being positive before my Anti dsDNA was positive. In Sjgren syndrome there will often be a speckled pattern; in scleroderma there will be a nucleolar pattern; and in limited scleroderma (i.e., CREST syndrome [calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia]) there will be a pattern of centromere staining. So can hypoglycemia, which often occurs in lupus. interservice rivalry japan hoi4. WebSpeckled: A speckled staining pattern means fine, coarse speckles of ANA are present throughout the nucleus. By using our website, you consent to our use of cookies. You might first ask, What is the best method for ANA testing? Most of us (people with Lupus) either get a rash from the sun, or we have an increase in symptoms (a flare). But it does not say anything about the type of fish or what the fish are doing. Current concepts and future directions for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. than you. Don't Miss Dangerous Situations. Always being cold could be a sign of thyroid problems. shaky hands, rash on neck, bad taste in mouth,fatique? At HealthMatters, we're committed to maintaining the security and confidentiality of your personal information. Is a high ana titer of 1:640 or > and symptoms present for ctd early in diagnosis likely mean a bad prognosis or not necessarily? The ANA test result can sometimes also be positive if you have one of these conditions:Raynaud's syndrome -- a disease that makes your fingers and toes turn blue and feel coldThyroid diseases -- Hashimoto's thyroiditis, Grave's diseaseLiver diseases -- autoimmune hepatitis, primary biliary cirrhosisInflammatory bowel diseaseLung diseases -- idiopathic pulmonary fibrosisCancerViral infections
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