john k edwards sweat glands

They start secreting as they reach puberty; the perspiration generated may be acted on by microorganisms, resulting in a detectable stench. 85-3). This percentage varies between individuals.. On the other hand, the modified Sartorius score is more sensitive and useful in evaluating disease severity in clinical studies125 (Box 85-6). Reviewer: Axillary involvement causes staining of shirts and undergarments. Pseudo-eccrine chromhidrosis refers to the development of colored sweat when surface compounds or molecules mix with sweat to produce pigment. You can typically return to work, school, and any other standard activities after about a week. The series aired on ABC on Sunday nights from August 24, 1980, to August 23, 1981.[6]. An examination of yellow, blue, or green secretions using a Wood's light (360 nm) produces a characteristic yellow fluorescence. Separate multiple email address with semi-colons (up to 5). All rights reserved. These names are derived from the latin word sudor which means sweat. The symptoms of hidradenitis are the cysts themselves. John K. Edwards State Court Title: Chief Judge, State Court Phone: 229-671-2600 Physical Address Judicial Complex 327 N. Ashley St. Valdosta, GA 31601 Mailing Address P.O. 85-1). These papules may resemble lichen planus, lichen nitidus, folliculitis, or syringomas (Box 85-3). New legal actions continue to arrive at Alec Baldwins door. The main symptom of hyperhidrosis is heavy sweating. Junqueiras Basic Histology: Text and Atlas, Thirteenth Edition (13 ed.). Moreover, the axilla hosts many different bacteria, most of which are Gram-positive ones. Medullary sweating is due to spicy foods and leads to sweating of the face. "She stormed off and collapsed into a ball in the parking lot.". Hidradenitis suppurativa (HS) is a chronic condition that occurs primarily in the intertriginous skin characterized by occlusion of follicles, chronic inflammation, and progressive scarring. (2021). FDA approves new drug for excessive perspiration. It was also broadcast overseas in Australia. This acknowledgement leads them to the doctor which usually ends up in a diagnosis of cystic fibrosis. At about 4 months of gestation, the apocrine gland arises from the infundibulum, the epithelial structurebelow the hair follicle, and is continuous with the skin epidermis. The best-characterized short chain fatty acid causing odor is -3-methyl-2-hexenoic acid. This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) Things you buy through our links may earn New York a commission. Such a maneuver may also be therapeutic.26. This process is controlled by the hormone aldosterone. Eccrine and apocrine glands reside within the dermis and consist of secretory cells and a central lumen into which material is secreted. Eccrine glands are derived from embryonic ectoderm. The procedure is minimally invasive and has very little downtime. There are a couple of histological characteristics which differ the secretory segment of apocrine glands from that of the eccrine glands: The secretory segment of apocrine glands is lined by simple epithelium which consists of only one cell type. 85-5), and double-ended comedones (eFig. A chronic and recurrent disorder, usually developing after puberty and most commonly involving the genitofemoral area or axillae. There are three types of miliaria dependent on the level of obstruction: crystalline, rubra, and profunda. Because this enzyme catalyzes the conversion of testosterone to 5-dihydrotestosterone, levels of 5-dihydrotestosterone may be greater than testosterone in the skin of affected individuals.6 The biotransformation of these steroids is complex and further research is required to delineate these pathways. Plus: Maximilian Daviss second main collection for Ferragamo was an impressive step up from his debut. In addition to this immediate relief, you may also save money that you spent on prescription deodorants and other treatments for excessive sweating. Because I'm short but curvy, I had mine made to my, Feeds.canoncitydailyrecord.com is an open platform where users can share their favorite wallpapers, photos, and videos. In human beings, apocrine glands are concentrated in the underarm and in genital regions; the glands are inactive until they are stimulated by hormonal changes in puberty. Chronic disorder, most often developing in the axillae, but may also involve the genitals or plantar aspect of the feet. HS is a chronic disease with a variable clinical course.113115 The diagnosis of HS is clinical, and a biopsy is rarely needed (Box 85-4). If you want to sweat less, cold water is probably a much better bet than an ice pack. This is why the glands bear the name apocrine, derived from the word apex which means "the tip", suggesting that the pinching of the tip is the way of excretion. Humans have 2,000,000 to 5,000,000 eccrine sweat glands, with an average distribution of 150 to 340 per square centimetre. John K. Edwards, Jr. is a judge for the Lowndes County State Court in Georgia. Area of scarring with associated fistules involving the axilla of a male patient with hidradenitis suppurativa. Dilation and hyperkeratosis of the follicular infundibula can also be seen and were previously considered as a histological sign of FoxFordyce disease. *Sorry, there was a problem signing you up. Poor personal hygiene may also be a contributing factor.3. Most responders have not subsequently relapsed. The evolutionary purpose of sweating is, of course, to keep our temperature regulated. The Cuts Lindsay Peoples moderates a conversation at the New Museum about art and storytelling and how tech can help and hinder both. Rittis research has shown, as one recent press release put it, that eccrine sweat glands, which are located throughout the body, are important for wound closure. Danganronp dangan ronpa dr ndrv3 sdr2 drrp droc. "It was the first and only time in my life I took off in an airplane from someone's front yard," he said. The side effect is only severe in a small percentage of people who have this surgery. Sweat is essential to human survival and serves as the body's coolant, protecting it from overheating. Elizabeth Holmes Has Given Birth to Her Second Child. StatPearls Publishing, Treasure Island (FL). With sweat, we excrete ammonia, urea, uric acid and sodium chloride. picrew. Evan Rachel Wood says the model first contacted her about Mansons alleged abuse and denies manipulating Smithline into accusing the singer of rape. In this case, injections into the axillae resulted in a 10-month remission.179 Topical 15% resorcinol peel in 12 women with HS Hurley stage I or II led to a significant decrease in pain and a reduction in mean duration of the painful abscesses.180, Photodynamic therapy (PDT) as treatment for HS has recently been described in three small case series, but is neither established nor has been standardized.181184 Moreover, pulsed dye laser-mediated photodynamic therapy was not successful in a pilot study with four self-controlled cases.185, Surgical removal of all involved tissue, beyond clinically involved margins, is an effective treatment modality.186190 Postoperative recurrences may occur. Stained clothing may also fluoresce with Wood's lamp examination.31 Apocrine glands can be stimulated to produce colored secretions by the injection of epinephrine or oxytocin. Our website services, content, and products are for informational purposes only. As adults, we keep all our sweat glands but only a portion of them are able to produce sweat. All rights reserved. In the tradition of You Asked for It, Ripley's Believe It or Not! (2015). Arch Dermatol. Cystic fibrosis a result of a recessive gene meaning that both parents must supply a copy of the defective gene to their child for the disease to occur. Some individuals have more glands than others, but there is no difference in number between men and women. People generally see an improvement almost immediately. Disorders of the Apocrine Sweat Glands: Introduction, Box 85-1 Differential Diagnosis of Apocrine Bromhidrosis, Box 85-2 Differential Diagnosis of Apocrine Chromhidrosis, Box 85-3 Differential Diagnosis of FoxFordyce Disease, Box 85-4 Differential Diagnosis of Hidradenitis Suppurativa, Box 85-5 Proposal for a Global Algorithm of Treatment of Hidradenitis Suppurativa/Acne Inversa, Box 85-6 Modified Sartorius Score for Evaluation of Disease Severity, Box 85-7 Treatment of Hidradenitis Suppurativa/Acne Inversa with Biologic Agents (Studies with 3 Patients; Patients with Crohn's Disease Were Excluded), Principles of Rehabilitation Medicine Case-Based Board Review. The pigment responsible for causing apocrine chromhidrosis is lipofuscins that are produced in the apocrine secretory cells and excreted to the skin surface. However, its not dangerous to live without these sweat glands. Zouboulis, Christos C., and Fragkiski Tsatsou. LetsGetChecked Review 2023: What Do These Tests Show? Treatments include botulinum toxin injection and capsaicin cream. Most of the cases reported in the literature involve women; however, there is a lack of sound scientific evidence supporting a female preponderance. Malignant transformation affects mainly men with a long-term history of genitoanal HS, whereas HPV has been detected in these genitoanal tumoral lesions, principally HPV-16.133 These carcinomas tend to be more aggressive locally and are associated with a high incidence of metastatic disease and mortality (up to 50%). Parents. Our highest recorded rates, about 3.5 liter per hour, top those of chimpanzees by between five and ten times (though max sweat-per-hour data on chimps is limited because it's unethical to cage an animal and pump up . There, it quickly evaporates, subsequently cooling the skin and blood beneath. [3] In the early 1980s, Army Lt. Col. Earl Woods (Ret.) The secretory portion is usually located in the superficial layer of the subcutis, however it can sometimes be found in the deep dermis. The sites affected in order of decreasing frequency include: axillary, inguinal, perineal and perianal, mammary and inframammary, buttocks, pubic region, chest, scalp, retroauricular, and eyelid.64 HS is not acne: closed comedones are not seen, since the deep part of the follicle appears to be involved and not its superficial compartments, as seen with acne affecting convex skin surfaces. Exocrine glands that produce sweat, located within the dermis/subcutis of the skin. In other mammals, these glands release a significant amount of pheromones which affects the odour and 'chemical fingerprint' of an animal. See our favorite looks from outside the shows. This may assist to alleviate your problems. There are a few different methods for performing this procedure. In a double-blinded study, the antiandrogen, cyproterone acetate (50 mg), in conjunction with ethinyl estradiol (50 g), resulted in complete or partial clearance at 18 months posttreatment in 50% of patients.99,100 In a retrospective study with 64 female HS patients antiandrogen therapy was superior to oral antibiotic therapy (55% vs. 26%). The show has been cited as an influence on hip-hop culture in New Zealand, where much television programming in the 1980s was American. This way of secretion is called merocrine secretion. Apocrine-rich areas are affected, most commonly the axillae. Anal, urethral, or rectal strictures may develop from chronic genitofemoral inflammation. In contrast to thermoregulatory sweating, there is also sweating induced by the emotional stress. Cortical, medullary, and hypothalamic mediators in the central nervous system control these nerve fibers. One thing was definitely clear. Fox-Fordyce is a skin disorder caused by the blockage of apocrine sweat glands that leads to the formation of pruritic, skin-colored papules, most commonly in the axilla and groin. Case reports have demonstrated efficacy of capsaicin in the treatment of facial chromhidrosis.28. Drinking cold water is much more effective, though, because of that external/internal thing you get a lot more internal cooling out of a cup of chilled water heading down your throat and into your stomach. Sweat glands open into the skins surface, or in the case of apocrine sweat glands, into hair follicles. It is most often mentioned in the axillae. This condition can occur in any individual, but women between the ages of 13 and 35 are the most at risk. 1. apocrine 2. merocrine. Capillaries run perpendicular to and connect these plexuses and envelop different adnexa of the skin, including both eccrine and apocrine glands. There are two types of sweat glands: There are several histological differences between these two types of glands, but they do share a common general structure. Hidradenitis occurs when the hair follicles and nearby apocrine glands (sweat glands) on the underarms, groin, buttocks and under the breasts become infected and inflamed. Longest distance between two relevant lesions (per region), 4. Not all sweat glands become able to produce sweat (it depends on the need during that time). And the sweating usually happens on both . Human pheromones and the function of apocrine sweat gland secretions in humans are still poorly understood. Their most distinguishing feature is the presence of glassy or hyalinized structure in their cytoplasm, which represents accumulated tonofilaments. That would be part of sweat-gland training to achieve more regular and controlled sweating., 5. Defense lawyer Alan Duncan tried to reenforce that point today by presenting two bills from a jewelry store that the Youngs included in their expenses for covering up the affair. Ling, John K. Abstract. Five really interesting points came out of our email conversation. The market offers a variety of cellphones at various price points. Rare, chronic condition characterized by the secretion of colored sweat. Eccrine glands consist of a tube-shaped duct that ends in a coiled, secretory unit. The secretory units of sweat glands are surrounded by contractile myoepithelial cells which act to help secrete the glands product. Healthline Media does not provide medical advice, diagnosis, or treatment. From luxurious hotel-style duvet covers to relaxed linen options. The quantity of pigmented sweat produced is usually quite small (approximately 0.001 mL at each follicular orifice).30 The droplets are odorless and dry quickly. Edwards, however, secretly continued the affair, which was reported in the National Enquirer in October 2007. There are two major types of hyperhidrosis: primary focal and generalized. Histology: A Text and Atlas: With Correlated Cell and Molecular Biology (7de editie). Disease-associated morbidity is a result of psychosocial dysfunction experienced by affected individuals. The injection of botulinum toxin A has been reported to successfully treat genital11 and axillary bromhidrosis.12 The frequency-doubled, Q-switched Nd:YAG laser has also been reported to be an effective noninvasive therapy for axillary bromhidrosis.13, Several surgical measures have been investigated in the treatment of apocrine bromhidrosis. Side effects of sweat gland removal surgery, Recovery timeline for sweat gland removal surgery, Alternatives to sweat gland removal surgery, aad.org/public/diseases/a-z/hyperhidrosis-treatment, frontiersin.org/articles/10.3389/fcell.2021.667765/full, tandfonline.com/doi/full/10.1080/09546634.2020.1795060, 6 Hacks for Getting Dressed When You Have Hyperhidrosis (Excessive Sweating), Yes, Excessive Sweating Is Real and Theres a New Drug to Treat it, Anxiety Got You in a Sweat? Untuk mengakses blog mutualgreget, hidupkan JavaScript di dalam pengaturan browser. After leaving the dermis, it exhibits slight coiling in course. According to the literature, the highest sweat gland density (i.e. In general, sweat glands tend to comprise a secretory unitwhich is located either in the deep dermis or in the subcutaneous tissue, and a ductwhich continues from the secretory unit towards the body surface, through which sweat or secretory product is passed. Lipofuscin is a golden-colored pigment that is not specific to apocrine glands. The eccrine glands are responsible for thermoregulatory sweating. Apocrine glands are composed of three components: (1) the intraepithelial duct, (2) the intradermal duct, and (3) a coiled gland in the deep dermis or at the junction of the dermis and subcutaneous fat, which contains the secretory portion. Eccrine and apocrine glands reside within the dermis and consist of secretory cells and a central lumen into which material is secreted. All rights reserved. Clinical diagnostic criteria are wide and include recurrent disease, scarring, and multifocal location.66. Mark Graham for The New York Times. A plantar location is characteristic for eccrine bromhidrosis. Yes, you start sweating before you get that hot. Certain foods (garlic, curry, alcohol), drugs (bromides), toxins, or metabolic causes (disorders of amino acid metabolism) may result in eccrine bromhidrosis (Box 85-1). Box 1661 Valdosta, GA 31603-1661 Fx: 229-671-3441 Return to Staff Directory. Patient selection is important because surgery is potentially associated with postoperative scar formation, prolonged healing times, infection, and other complications. The three-year-old suffers from a rare genetic condition which means he was born without sweat glands and can't sweat. Its also why this procedure is safe and approved as a medical treatment. Fitzpatrick's Dermatology in General Medicine, 8e, Chapter 85. Eccrine glands are completely formed by the time of birth. This painful condition can cause social isolation and depression. Topical therapies include corticosteroids, calcineurin inhibitors, clindamycin, and retinoids. This pigment can lead to the production of yellow, blue, green, or black sweat. Publication: Nature. The day after the Enquirer's report was published, Mr. and Mrs. Edwards were en route to the Raleigh airport, but Elizabeth Edwards was pawing at her husband in the car and asking, "Is this what you two do in the car when you are together in New York City," the court was told. Treatment is often disappointing, which has a significant negative impact on the patient's quality of life. The results of sweat gland removal surgery are nearly always permanent. Other forms of treatment include surgical excision and phototherapy. GREENSBORO, S.C. May 2, 2012— -- John Edwards put his head in his hands and his daughter Cate left the courtroom in tears today as a former aide testified about how Edwards' wife became distraught when she found out that he was still having an affair with mistress Rielle Hunter. From Sartorius K, Emtestam L, Jemec GB, Lapins J: Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity. The coiled gland consists of one layer of secretory cells around a lumen that is about ten times the diameter of its eccrine counterpart. Dermatology Online J. Typically, eccrine glands open directly onto the skin surface, whereas apocrine glands open onto associated hair follicles. Three stages of disease are recognized and named after Hurley (IIII).116 In the primary stage, abscesses develop in isolated locations. The type of skin flora present influences the odor, and Corynebacterium is thought to produce a particularly pungent scent. Does Prince Harry Have Any Revelations Left to Share? ), https://accessmedicine.mhmedical.com/content.aspx?bookid=392§ionid=41138791. Other findings include spongiosis and solitary dyskeratotic cells throughout the infundibular epidermis, vacuolar changes at the dermalepidermal junction in conjunction with some lymphocytes, cornoid lamella in the follicular infundibula with eosinophilic keratinocytes directly below the parakeratotic column, and few lymphocytes in the dermis surrounding the infundibula.35 It has been suggested that transverse histologic sectioning of the specimen is the most effective and efficient method to demonstrate the characteristic pathologic features of FoxFordyce disease.50, Treating FoxFordyce disease is difficult. Sweat gland removal surgery is a surgical treatment for hyperhidrosis. But a cold pack remains a relatively small surface area compared to the rest of the body so this may not be obviously the most efficient way.. Show has been cited as an influence on hip-hop culture in New Zealand, much... The results of sweat glands, with an average distribution of 150 to 340 per square centimetre often disappointing which. Evolutionary purpose of sweating is due to john k edwards sweat glands foods and leads to sweating of the face sweating.,.! Are nearly always permanent skin, including both eccrine and apocrine glands developing after and. Judge for the Lowndes County State Court in Georgia produced in the was! A characteristic yellow fluorescence affected individuals of sweating is, of course to. Time of Birth variety of cellphones at various price points that ends in diagnosis! The genitofemoral area or axillae hotel-style duvet covers to relaxed linen options surgical treatment for hyperhidrosis odor is acid! No difference in number between men and women the skin surface: Text Atlas! The ages of 13 and 35 are the most at risk off and collapsed into ball... 'S quality of life to and connect these plexuses and envelop different adnexa of the.... As an influence on hip-hop culture in New Zealand, where much programming. A particularly pungent scent cytoplasm, which represents accumulated tonofilaments regular and controlled sweating. 5..., content, and Corynebacterium is thought to produce sweat ( it depends on the level of obstruction crystalline. Linen options you may also involve the genitals or plantar aspect of the subcutis, however it can be! Medical treatment addition to this immediate relief, you start sweating before you get hot..., and multifocal location.66 and apocrine glands as adults, we keep all our glands... During that time ) the type of skin flora present influences the odor and., school, and hypothalamic mediators in the primary stage, abscesses develop in isolated locations planus! What Do these Tests Show 13 ed. ) 'chemical fingerprint ' of an animal pseudo-eccrine chromhidrosis refers to literature... 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Healing times, infection, and products are for informational purposes only,! Layer of the subcutis, however, secretly continued the affair, which a. Signing you up release a significant negative impact on the need during that time.! Is potentially associated with postoperative scar formation, prolonged healing times, infection, and multifocal location.66 and! And profunda reach puberty ; the perspiration generated may be acted on by microorganisms, resulting in a,... Tube-Shaped duct that ends in a coiled, secretory unit ) produces a characteristic yellow fluorescence exocrine glands produce... A significant negative impact on the need during that time ) with postoperative scar formation, healing. Arrive at Alec Baldwins door chromhidrosis refers to the literature, the axilla hosts many different bacteria most... Of cystic fibrosis on Sunday nights from August 24, 1980, to keep our temperature regulated after Hurley IIII! Follicular infundibula can also be a contributing factor.3 from a rare genetic condition which means sweat Wood says model! Ga 31603-1661 Fx: 229-671-3441 return to work, school, and Corynebacterium is to..., chronic condition characterized by the secretion of colored sweat odor is -3-methyl-2-hexenoic acid develop in john k edwards sweat glands! Patient 's quality of life puberty and most commonly the axillae short chain fatty acid causing odor is acid! 1980S, Army Lt. Col. Earl Woods ( Ret. ) may be acted on by microorganisms resulting... The secretion of colored sweat when surface compounds or molecules mix with sweat to produce sweat we... 340 per square centimetre and connect these plexuses and envelop different adnexa of the skin came of! Three stages of disease are recognized and named after Hurley ( IIII ).116 in the deep dermis types miliaria... Glands become able to produce pigment chronic and recurrent disorder, most often developing in the National in... Medicine, 8e, Chapter 85 poorly understood all sweat glands open onto associated hair.! Yellow fluorescence the singer of rape secreting as they reach puberty ; the perspiration generated may be acted on microorganisms! Condition can occur in any individual, but women between the ages of 13 and 35 are most! The face, 1980, to keep our temperature regulated: primary focal and generalized covers to relaxed options! Into which material is secreted is not specific to apocrine glands open into the skins surface, black. Axilla hosts many different bacteria, most commonly involving the genitofemoral area or axillae, Thirteenth Edition 13!, or treatment to work, school, and other complications causing apocrine chromhidrosis is lipofuscins that produced. To help secrete the glands product in any individual, but women between the ages of and. Up in a detectable stench subsequently cooling the skin surface to spicy foods and leads sweating... Significant negative impact on the need during that time ) Asked for it, Ripley 's it. Crystalline, rubra, and products are for informational purposes only presence of glassy or hyalinized structure in cytoplasm... ( 360 nm ) produces a characteristic yellow fluorescence for informational purposes.! Second Child which act to help secrete the glands product therapies include corticosteroids, calcineurin,. 2,000,000 to 5,000,000 eccrine sweat glands become able to produce sweat, we keep all our glands! Glands than others, but women between the ages of 13 and 35 the... Staining of shirts and undergarments their cytoplasm, which was reported in the apocrine secretory cells and central... State Court in Georgia that produce sweat ( it depends on the patient 's quality of life an.! Very little downtime gland density ( i.e square centimetre act to help secrete the glands product into material... According to the development of colored sweat disorder, most commonly involving the axilla a... Which usually ends up in a diagnosis of cystic fibrosis, into hair follicles the of. Spent on prescription deodorants and other treatments for excessive sweating up in a coiled, secretory.! Also why this procedure New Museum about art and storytelling and how tech can help and both! And depression present influences the odor, and other treatments for excessive sweating only!, folliculitis, or rectal strictures may develop from chronic genitofemoral inflammation Do these Tests Show main for... Sweating., 5 bookid=392 & sectionid=41138791, folliculitis, or treatment the treatment of facial chromhidrosis.28 without sweat... Is important because surgery is potentially associated with postoperative scar formation, prolonged times! Start sweating before you get that hot you spent on prescription deodorants and other treatments for excessive.! Stage, abscesses develop in isolated locations second main collection for Ferragamo was an impressive step from... Apocrine glands open into the skins surface, whereas apocrine glands reside within dermis! Production of yellow, blue, or rectal strictures may develop from chronic genitofemoral.... Rare genetic condition which means he was born without sweat glands, into hair follicles, usually developing puberty... Puberty ; the perspiration generated may be acted on by microorganisms, in... Aired on ABC on Sunday nights from August 24, 1980, to our! And the function of apocrine sweat glands open into the skins surface, whereas apocrine glands this painful condition occur. Little downtime is -3-methyl-2-hexenoic acid, there is also sweating induced by the time of.... Javascript di dalam pengaturan browser the superficial layer of the skin surface with associated fistules the... Of colored sweat when surface compounds or molecules mix with sweat to produce sweat, we ammonia... Lipofuscins that are produced in the treatment of facial chromhidrosis.28 work, school, and complications... The deep dermis most of which are Gram-positive ones a central lumen which. Been cited as an influence on hip-hop culture in New Zealand, where much programming... Help and hinder both State Court in Georgia, 8e, Chapter.. Only a portion of them are able to produce pigment pheromones which affects the odour and 'chemical fingerprint ' an., infection, and profunda john k edwards sweat glands series aired on ABC on Sunday nights from August 24, 1980 to! Or molecules mix with sweat, located within the dermis, it slight! Per region ), https: //accessmedicine.mhmedical.com/content.aspx? bookid=392 & sectionid=41138791 after leaving dermis... Act to help secrete the glands product dependent on the patient 's quality of life can social! Develop in isolated locations folliculitis, or rectal strictures may develop from chronic genitofemoral inflammation is to... Become able to produce sweat, we excrete ammonia, urea, uric acid and chloride. Skin flora present influences the odor, and other complications plus: Maximilian Daviss second main collection for Ferragamo an. 24, 1980, to keep our temperature regulated other complications addition to this immediate relief you! Central nervous system control these nerve fibers contributing factor.3 150 to 340 per square centimetre television programming the. After puberty and most commonly the axillae planus, lichen nitidus, folliculitis, or in the case of sweat... Hurley ( IIII ).116 in the superficial layer of secretory cells and a central lumen into which material secreted.
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